Gout has been a commonly occurring disease throughout history. Henry the Eighth is one of the most famous gout sufferers. Benjamin Franklin also suffered from the disease.  Approximately 5 million Americans have been diagnosed with gout. It has been estimated that 275 of every 100,000 people suffer from gout. Gout does occur in both men and women but occurs most commonly in men. The disease generally strikes males after puberty. In men, the first attack of gout usually occurs at 30 to 40 years of age. In women, the disease is usually postmenopausal.

Gout is a form of arthritis and affects the joints. As a matter of fact, gout is one of the most common types of arthritis. Any joint in the body can be affected by gout. Usually, only one or a few joints are affected. The disease usually involves the feet and legs, but the hands may also be affected. The toe joint is the joint most commonly affected by the disease. Seventy-five percent of first attacks involve the big toe. The knee joints and ankle joints are also commonly affected. Gout can be very painful. Gout occurs in episodes called attacks. An attack may last several days. Gout tends to be a recurring disease, and episodes may occur repeatedly unless the underlying cause is treated. Although some people may only have one attack of gout, the disease often becomes chronic. Repeated attacks of gout can cause harm to the joints and tendons and lead to chronic arthritis.

Gout results from abnormally high levels of uric acid. High levels of uric acid in the blood may be caused by an overproduction of the substance or reduced kidney function. Gout often occurs as a result of an inherited inability to metabolize uric acid efficiently.  If the kidneys cannot get rid of uric acid, it remains in the body. Although high levels of uric acid in the blood are usually not harmful, the uric acid may leave the bloodstream and accumulate in the joints. The uric acid forms hard, sharp crystals in the joints, and these crystals cause pain. Uric acid crystals may accumulate in the joints over an extended period of time. Chronic gout can lead to the formation of large lumps of uric acid in the joints. This can cause chronic inflammation of the affected area. 

An attack of gout may come on suddenly and often begins at night. The affected joint rapidly becomes inflamed. The attack is caused by the deposition of uric acid crystals in the synovial fluid and synovial lining. Synovial fluid is the fluid that surrounds the joints. The synovial lining is the tissue that lines the joints. The affected joint becomes inflamed as the body responds to the presence of the uric acid crystals. Gout presents with throbbing pain accompanied by stiffness and swelling. The affected joint may appear warm and red. Gout causes pain in two ways. The sharp uric acid crystals themselves cause pain when the joint is moved. The inflammation around the joint causes the affected issue to become swollen and painful to the slightest pressure. A joint affected by gout is tender to the touch. Fever may accompany a gout attack. It is by far the most painful form of arthritis and poses one of the highest risks for joint degeneration and deformity if it is not gained control of properly.

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